Variational assimilation for xenon dynamical forecasts in neutronic using advanced background error covariance matrix modelling

Data assimilation method consists in combining all available pieces of information about a system to obtain optimal estimates of initial states. The different sources of information are weighted according to their accuracy by the means of error covariance matrices. Our purpose here is to evaluate the efficiency of variational data assimilation for the xenon induced oscillations forecasts in nuclear cores. In this paper we focus on the comparison between 3DVAR schemes with optimised background error covariance matrix B and a 4DVAR scheme. Tests were made in twin experiments using a simulation code which implements a mono-dimensional coupled model of xenon dynamics, thermal, and thermal–hydraulic processes. We enlighten the very good efficiency of the 4DVAR scheme as well as good results with the 3DVAR one using a careful multivariate modelling of B

Differential influence of instruments in nuclear core activity evaluation by data assimilation

The global activity fields of a nuclear core can be reconstructed using data assimilation. Data assimilation allows to combine measurements from instruments, and information from a model, to evaluate the best possible activity within the core. We present and apply a specific procedure which evaluates this influence by adding or removing instruments in a given measurement network (possibly empty). The study of various network configurations of instruments in the nuclear core establishes that influence of the instruments depends both on the independant instrumentation location and on the chosen network

Robustness of nuclear core activity reconstruction by data assimilation

We apply a data assimilation techniques, inspired from meteorological applications, to perform an optimal reconstruction of the neutronic activity field in a nuclear core. Both measurements, and information coming from a numerical model, are used. We first study the robustness of the method when the amount of measured information decreases. We then study the influence of the nature of the instruments and their spatial repartition on the efficiency of the field reconstruction

Synthesis of ternary transition metal fluorides Li 3MF 6via a sol-gel route as candidates for cathode materials in lithium-ion batteries

A sol-gel route for ternary lithium fluorides of transition metals (M) is presented allowing the synthesis of Li 3MF 6-type and Li 2MF 5-type compounds. It is based on a fluorolytic process using transition metal acetylacetonates as precursors. The domain size of the obtained powders can be controlled by modifying the conditions of synthesis. 6Li and 7Li magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectroscopy is used to study local environments of the Li ions in orthorhombic and monoclinic Li 3VF 6 as well as Li 2MnF 5. The number of magnetically inequivalent Li sites found by MAS NMR is in agreement with the respective crystal structure of the compounds studied. Quantum chemical calculations show that all materials have high de-lithiation energies making them suitable candidates to be used as high-voltage battery cathode materials. © 2012 The Royal Society of Chemistry

Different Operation Regimes at the KIT Storage Ring KARA (Karlsruhe Research Accelerator)

The KIT storage ring KARA operates in a wide energy range from 0.5 to 2.5 GeV. Different operation modes have been implemented at KARA, so far, the double-bend achromat (DBA) lattice with non-dispersive straight sections, the theoretical minimum emittance (TME) lattice with distributed dispersion, different versions of low-compaction factor optics with highly stretched dispersion function. Short bunches of a few ps pulse width are available at KARA. Low-alpha optics has been simulated, tested and implemented in a wide operational range of the storage ring and is now routinely used at 1.3 GeV for studies of beam bursting effects caused by coherent synchrotron radiation in the THz frequency range. Different non-linear effects, in particular residual high-order components of the magnetic field, generated in high-field superconducting wigglers have been studied and cured. Based on good agreement between computer simulations and experiments, a new operation mode at high vertical tune was implemented. The beam performance during user operation as well as at low-alpha regimes has been improved. A specific optic with negative compaction factor was simulated, tested and is in operation

Characterizing temporary hydrological regimes at a European scale

Monthly duration curves have been constructed from climate data across Europe to help address the relative frequency of ecologically critical low flow stages in temporary rivers, when flow persists only in disconnected pools in the river bed. The hydrological model is 5 based on a partitioning of precipitation to estimate water available for evapotranspiration and plant growth and for residual runoff. The duration curve for monthly flows has then been analysed to give an estimate of bankfull flow based on recurrence interval. The corresponding frequency for pools is then based on the ratio of bank full discharge to pool flow, arguing from observed ratios of cross-sectional areas at flood 10 and low flows to estimate pool flow as 0.1% of bankfull flow, and so estimate the frequency of the pool conditions that constrain survival of river-dwelling arthropods and fish. The methodology has been applied across Europe at 15 km resolution, and can equally be applied under future climatic scenarios

H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that antiviral resistant viruses emerge and spread in the human population. The 2009 pandemic H1N1 virus is already resistant to adamantanes. Recently, a novel neuraminidase inhibitor resistance mutation I223R was identified in the neuraminidase of this subtype. To understand the resistance mechanism of this mutation, the enzymatic properties of the I223R mutant, together with the most frequently observed resistance mutation, H275Y, and the double mutant I223R/H275Y were compared. Relative to wild type, KMvalues for MUNANA increased only 2-fold for the single I223R mutant and up to 8-fold for the double mutant. Oseltamivir inhibition constants (KI) increased 48-fold in the single I223R mutant and 7500-fold in the double mutant. In both cases the change was largely accounted for by an increased dissociation rate constant for oseltamivir, but the inhibition constants for zanamivir were less increased. We have used X-ray crystallography to better understand the effect of mutation I223R on drug binding. We find that there is shrinkage of a hydrophobic pocket in the active site as a result of the I223R change. Furthermore, R223 interacts with S247 which changes the rotamer it adopts and, consequently, binding of the pentoxyl substituent of oseltamivir is not as favorable as in the wild type. However, the polar glycerol substituent present in zanamivir, which mimics the natural substrate, is accommodate

Resonant nonlinear magneto-optical effects in atoms

In this article, we review the history, current status, physical mechanisms, experimental methods, and applications of nonlinear magneto-optical effects in atomic vapors. We begin by describing the pioneering work of Macaluso and Corbino over a century ago on linear magneto-optical effects (in which the properties of the medium do not depend on the light power) in the vicinity of atomic resonances, and contrast these effects with various nonlinear magneto-optical phenomena that have been studied both theoretically and experimentally since the late 1960s. In recent years, the field of nonlinear magneto-optics has experienced a revival of interest that has led to a number of developments, including the observation of ultra-narrow (1-Hz) magneto-optical resonances, applications in sensitive magnetometry, nonlinear magneto-optical tomography, and the possibility of a search for parity- and time-reversal-invariance violation in atoms.Comment: 51 pages, 23 figures, to appear in Rev. Mod. Phys. in Oct. 2002, Figure added, typos corrected, text edited for clarit

Mould Routine Identification in the Clinical Laboratory by Matrix-Assisted Laser Desorption Ionization Time-Of-Flight Mass Spectrometry

BACKGROUND: MALDI-TOF MS recently emerged as a valuable identification tool for bacteria and yeasts and revolutionized the daily clinical laboratory routine. But it has not been established for routine mould identification. This study aimed to validate a standardized procedure for MALDI-TOF MS-based mould identification in clinical laboratory. MATERIALS AND METHODS: First, pre-extraction and extraction procedures were optimized. With this standardized procedure, a 143 mould strains reference spectra library was built. Then, the mould isolates cultured from sequential clinical samples were prospectively subjected to this MALDI-TOF MS based-identification assay. MALDI-TOF MS-based identification was considered correct if it was concordant with the phenotypic identification; otherwise, the gold standard was DNA sequence comparison-based identification. RESULTS: The optimized procedure comprised a culture on sabouraud-gentamicin-chloramphenicol agar followed by a chemical extraction of the fungal colonies with formic acid and acetonitril. The identification was done using a reference database built with references from at least four culture replicates. For five months, 197 clinical isolates were analyzed; 20 were excluded because they were not identified at the species level. MALDI-TOF MS-based approach correctly identified 87% (154/177) of the isolates analyzed in a routine clinical laboratory activity. It failed in 12% (21/177), whose species were not represented in the reference library. MALDI-TOF MS-based identification was correct in 154 out of the remaining 156 isolates. One Beauveria bassiana was not identified and one Rhizopus oryzae was misidentified as Mucor circinelloides. CONCLUSIONS: This work's seminal finding is that a standardized procedure can also be used for MALDI-TOF MS-based identification of a wide array of clinically relevant mould species. It thus makes it possible to identify moulds in the routine clinical laboratory setting and opens new avenues for the development of an integrated MALDI-TOF MS-based solution for the identification of any clinically relevant microorganism